After escaping from Abstergo, Desmond Miles is led to an assassin safe house by Lucy Stillman, and accesses the genetic memories of Ezio Auditore da Firenze, his ancestor from 15th Century Renaissance Italy. After witnessing his father and brothers murdered, Ezio becomes an assassin and vows revenge on those who committed the crime. With the help of family and real historical figures, including Leonardo da Vinci, Ezio uncovers a greater conspiracy which would lead him directly to the religious hub of the world and a Spaniard by the name of Rodrigo Borgia, the man who would become Pope Alexander VI...